MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection

MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection

Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel human coronavirus that emerged in 2012, causing severe pneumonia and acute respiratory distress syndrome (ARDS), with a case fatality rate of ~36%. When expressed in isolation, CoV accessory proteins have been shown to interfere with innate antiviral signaling pathways. However, there is limited information on the specific contr...

RelAp43, a Member of the NF-κB Family Involved in Innate Immune Response against Lyssavirus Infection

NF-κB transcription factors are crucial for many cellular processes. NF-κB is activated by viral infections to induce expression of antiviral cytokines. Here, we identified a novel member of the human NF-κB family, denoted RelAp43, the nucleotide sequence of which contains several exons as well as an intron of the RelA gene. RelAp43 is expressed in all cell lines and tissues tested and exhibits...

MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic.

MERS-CoV

In 2002/03, a novel coronavirus (CoV) termed severe acute respiratory syndrome (SARS)-CoV emerged in China and caused an epidemic in which approximately 800 of 8000 cases died. Ten years later, a newly emerged Middle East respiratory syndrome (MERS)-CoV has been confirmed in 189 patients of which 82 had a fatal outcome. All MERS cases were linked to the Arabian Peninsula and to date thirteen ca...

Stimulus-selective crosstalk via the NF-κB signaling system reinforces innate immune response to alleviate gut infection

Tissue microenvironment functions as an important determinant of the inflammatory response elicited by the resident cells. Yet, the underlying molecular mechanisms remain obscure. Our systems-level analyses identified a duration code that instructs stimulus specific crosstalk between TLR4-activated canonical NF-κB pathway and lymphotoxin-β receptor (LTβR) induced non-canonical NF-κB signaling. ...